Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
July 12, 2021
 min read

Can I take Ibuprofen with CBD oil, and what to expect?

can i take ibuprofen with cbd oil
 Anthony Clement
Written by  
Anthony Clement
July 12, 2021

table of Contents

As you’re experimenting with CBD oil, there might be a period when you will use both Ibuprofen and medical hemp simultaneously. So, can I take Ibuprofen with CBD oil?

CBD tincture are commonly used as pain relievers. They might have some potential for chronic inflammation, as well as other ailments. As such, patients sometimes perceive medical hemp as a potential replacement for an Ibuprofen tablet.

In this article, we will analyze whether you can take Ibuprofen with CBD oil and what kind of interactions to expect.

Why do people use Ibuprofen?

Ibuprofen (brand name Advil) is a nonsteroidal anti inflammatory drug or NSAID. It is a stronger version of Acetaminophen (brand name Tylenol). This is the first approved over the counter drug from its class.

People use this product as a pain reliever. You can use it for moderate pain and chronic pain. Oftentimes, patients utilize it for dental or joint pain. It is especially popular for rheumatoid arthritis.

The product works by preventing the creation of prostaglandins. It does so by inhibiting the production of cyclooxygenase enzymes. They are the main cause of pain and inflammation. When we are injured or sick, the body will start producing a high amount of prostaglandins, which causes these issues. Besides pain and inflammation, the drug can also work for fever.

Ibuprofen is a fast acting product, which makes it ideal for people who have to deal with severe, sudden pain.

Why do I need CBD oil?

If you're already using Ibuprofen, you're probably wondering why you would need cannabidiol. The truth is, we don't know everything about CBD drug interactions and CBD oil benefits, which always brings certain risks.

The great thing about CBD cream and other CBD topicals, is that you can administer them on the skin. That way, you can address surface pain without having to ingest a strong medicine. While you shouldn’t completely disregard Ibuprofen and put your faith in medical hemp, in some cases, these products might provide a healthier alternative. If you were to combine these two, you would have to consider the adverse effects of the drug, as well as CBD.

Anyway, here are some of the ways cannabidiol might work for people who are already using Ibuprofen:


As previously mentioned, rheumatoid arthritis is one of the main reasons why people take this drug. It is a chronic condition, and there is very little you can do with the underlying problem. However, you might be able to use cannabidiol to remedy some of the symptoms.

Menstrual cramps

Menstrual pain and stomach bleeding can be really problematic. Luckily, it is a periodic problem. Instead of taking strong drugs, a person might consider using CBD products for minor relief. In this particular case, you should probably try CBD gummies and other edibles.

Dental pain

This is another type of sharp, unbearable pain. It is another example where cannabidiol might provide some pain relief. Unfortunately, most people would still go with traditional methods as you don’t want to experiment with alternative substances after a major procedure.

How would Ibuprofen and CBD oil work together?

It is really hard to predict the potential interaction between these two substances.

We don't know much about the cannabis plant and how it affects our bodies. Most experts focus on its impact on cannabinoid receptors and the endocannabinoid system. In a nutshell, the plant should be able to stimulate this system. By doing so, it would be able to harmonize various processes that the endocannabinoid system regulates, including stress, mood, pain, regeneration, sleep, and so on.

It is believed that CBD can restore homeostasis to the body, thus providing various minor and major benefits.

There was a minor study that could provide us with some valuable insights regarding its impact on pain. According to this research, cannabidiol might inhibit neurotransmitters and neuropeptides. Given that they have a direct impact on pain and inflammation, CBD might prevent these processes from occurring. Keep in mind that, while this study was interesting, it was performed on dogs. So, we cannot claim that humans would experience the same results.

On the other hand, we have Ibuprofen. This is a well researched drug that works by limiting the production of certain enzymes (Cytochrome P450)enzymes are essential for the metabolism of many medications.

It is regarded as a generally safe substance. However, it can still cause side effects such as stomach ulcers, high blood pressure, nausea, dizziness, headache, and so on.

If you were to add CBD oil to your Ibuprofen therapy, it might worsen some of these side effects. For example, both of these products may cause headaches and dizziness, so that's something you need to consider.

Medical hemp oil works similarly to grapefruit juice by inhibiting certain liver enzymes. This would prevent the normal metabolizing of the drugs. Foreign substances will remain in your body for a longer period of time, increasing the chance of drug related side effects.

How to take Ibuprofen and CBD oil?

Because of all the limitations and lack of knowledge, the best thing to do is to space doses. If you wish to take both, it is much better to take them at different times.

Like with other drugs, CBD will affect your liver enzymes, which will make Ibuprofen stay in your body for a prolonged period of time, thus increasing the odds of side effects, as well as their severity.

Ibuprofen will provide effects for 4 to 6 hours. It will remain in the body for 24 hours. So, it is best to use CBD oil 4 to 6 hours after taking Ibuprofen. Keep in mind that cannabidiol might last for variable periods of time depending on a product. For example, edibles will provide effects for up to 6 hours, while vapes will last for just 2 hours.

Topical items are the only thing you shouldn't worry about. They don't penetrate the bloodstream, nor should they interact with enzymes.

Is CBD oil safe?

CBD products are generally regarded as safe substances by the World Health Organization. They are even allowed for athletic use by the World Anti Doping Agency. But, as mentioned before, they can still cause side effects.

Among others, medical hemp might cause:

  • Drowsiness
  • Dizziness
  • Dry mouth and dry eyes
  • Changes in blood pressure and appetite
  • Diarrhea
  • Skin irritation

If you wish to combine CBD and Ibuprofen, perhaps it is best to try medical hemp by itself. That way, you can see how the substance affects you and if it causes side effects to your organism. Like many other chemicals of this type, you are more likely to experience drawbacks if you take a larger quantity of the product.

An important thing to note is that CBD oil shouldn't get you high. These products are made from the hemp plant, which has very low levels of psychoactive substance THC.

What is the optimal CBD dose?

There are a lot of factors you need to consider when administering CBD.

The optimal dosage will vary based on the patient's weight, tolerance, desired effect, age, product concentration, and so on. Most people will take somewhere between 20 to 30 milligrams of the substance per administration. The product can be applied several times a day.

Although this is regarded as a safe substance, and a high dose shouldn't cause any major issues, it still might increase the odds of side effects. Furthermore, the product can be expensive, so you don't want to use more than necessary.

The best way to establish your optimal dose is by starting with a smaller quantity and slowly increasing it. Even if you don't notice an instant improvement, continue using the product for a while. Medical hemp oil shows the best results after prolonged use. Furthermore, the product shouldn't cause toxicity or other unpredicted effects.

Hammell, D., Zhang, L., Ma, F., Abshire, S., Mcllwrath, S., Stinchcomb, A., Westlund, K., (2016), Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis, European Journal of Pain


Griffin, M., Mendelson, J., Mello, N., Lex, B., (1986), Marihuana use across the menstrual cycle, Drug and Alcohol Dependence


Gamble, L., J., Boesch, J., Frye, C., Schwark, W., Mann, S., Wolfe, L., Brown, H., Berthelsen, E., Wakshlag, J., (2018), Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs, Frontiers in Veterinary Science